RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-433
RNA ID
MI0001525
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
NA
Target
AZIN1;JNK1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
28149909
Title
Therapeutic potential of targeting microRNAs to regulate cardiac fibrosis: miR-433 a new fibrotic player
Year
2016
Function
"AZIN1 and JNK1 are targets of miR-433 in cardiac fibroblasts, and regulate fibroblast proliferation and myofibroblast differentiation, (ii) reduced AZIN1 expression activates TGF-beta/smad3 signalling in cardiac fibroblasts, (iii) decreased levels of JNK increase the phosphorylation of ERK, p38 kinase and smad3 and this contributes to fibroblast proliferation and the differentiation into myofibroblasts."